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Indole-3-carbinol attenuates lipopolysaccharide-induced acute respiratory distress syndrome through activation of AhR: role of CCR2+ monocyte activation and recruitment in the regulation of CXCR2+ neutrophils in the lungs

IntroductionIndole-3-carbinol (I3C) is found in cruciferous vegetables and used db hugger 20 as a dietary supplement.It is known to act as a ligand for aryl hydrocarbon receptor (AhR).In the current study, we investigated the role of AhR and the ability of I3C to attenuate LPS-induced Acute Respiratory Distress Syndrome (ARDS).MethodsTo that end, w

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